Wet granulation fine particle ethylcellulose tablets: Effect of production variables and mathematical modeling of drug release
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چکیده
منابع مشابه
Development and Evaluation of Extended Release Ethylcellulose Based Matrix Tablet of Diclofenac Sodium
Objective: The present study involved the preparation of Diclofenac sodium extended release hydrophobic matrix tablets formulated from Ethylcellulose polymer following its different grades, Ethocel Standard Premium and Ethocel Standard FP Premium. Methods: The matrix tablets were prepared with wet granulation method. Lubricated blends were characterized for physical properties like loose bulk d...
متن کاملDevelopment of novel diclofenac potassium controlled release tablets by wet granulation technique and the effect of co-excipients on in vitro drug release rates.
The aim of the present study was the formulation and evaluation of controlled release polymeric tablets of Diclofenac Potassium by wet granulation method for the release rate, release pattern and the mechanism involved in drug release. Formulations having three grades of polymer Ethocel (7P; 7FP, 10P, 10FP, 100P, 100FP) in several drugs to polymer ratios (10:3 and 10:1) were compressed into tab...
متن کاملFormulation and Evaluation of Extended- Release Tablet of Zolpidem Tartrate by Wet Granulation Technique
The goal of this study was to design and evaluate extended - release system of the hypnotic agent, Zolpidemtartrate usefulness for the treatment of insomnia. The half-life of this drug is about 1.9 - 3 hours that indicatingit a candidate for the extended release formulation. Our investigation relates to development of extendeddrug delivery system based on Hydroxy propyl methyl cellulose (HPMCK4...
متن کاملTheophylline-Ethylcellulose Microparticles: Screening of the Process and Formulation Variables for Preparation of Sustained Release Particles
Objective(s) The aim of this study was to formulate and evaluate microencapsulated controlled release preparations of theophylline using ethylcellulose as the retardant material with high entrapment efficiency. Materials and Methods Microspheres were prepared by water-in-oil-in-oil (W/O1/O2) emulsion-solvent diffusion (ESD). A mixed solvent system consisting of acetonitrile and dichloromet...
متن کاملIn Vitro Studies of Controlled Release Alfuzosin Matrix Tablets Prepared with Ethylcellulose and Hydroxypropyl Methylcellulose
Extended release formulation of alfuzosin, an a-antagonist used for prostatic hypertrophy, is available in market. It is convenient for older patients to take only one tablet a day. Marketed alfuzosin formulation is three layered geomatrix tablet that requires special facilities, high cost, more time and complex operation than normal direct compression formulation. Therefore, a less compl...
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ژورنال
عنوان ژورنال: AAPS PharmSci
سال: 2003
ISSN: 1522-1059
DOI: 10.1208/ps050213